General Information of the Compound
Compound ID
CP0506623
Compound Name
CHEMBL445111
    Show/Hide
Formula
C29H32N4O
Molecular Weight
452.602
Canonical SMILES
O=C(N[C@H]1CC[C@H](CCN2CCc3ccc(cc3CC2)C#N)CC1)c1ccnc2ccccc12
    Show/Hide
InChI
InChI=1S/C29H32N4O/c30-20-22-5-8-23-13-17-33(18-14-24(23)19-22)16-12-21-6-9-25(10-7-21)32-29(34)27-11-15-31-28-4-2-1-3-26(27)28/h1-5,8,11,15,19,21,25H,6-7,9-10,12-14,16-18H2,(H,32,34)/t21-,25-
    Show/Hide
InChIKey
WXWUAAQDRLQFOP-OKDASEJXSA-N
Physicochemical Property
logP
4.88598
Rotatable Bonds
5
Heavy Atom Count
34
Polar Areas
69.02
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
ChEMBL ID
CHEMBL445111
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1258.93 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 25.12 nM
   TI
   LI
   LO
   TS