General Information of the Compound
Compound ID
CP0504018
Compound Name
[2-[4-[[(E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl]amino]butyl]-3,4-dihydro-1H-isoquinolin-7-yl] trifluoromethanesulfonate
    Show/Hide
Structure
Formula
C25H30F3N3O4S
Molecular Weight
525.593
Canonical SMILES
CN(C)c1ccc(\C=C\C(=O)NCCCCN2CCc3ccc(OS(=O)(=O)C(F)(F)F)cc3C2)cc1
    Show/Hide
InChI
InChI=1S/C25H30F3N3O4S/c1-30(2)22-9-5-19(6-10-22)7-12-24(32)29-14-3-4-15-31-16-13-20-8-11-23(17-21(20)18-31)35-36(33,34)25(26,27)28/h5-12,17H,3-4,13-16,18H2,1-2H3,(H,29,32)/b12-7+
    Show/Hide
InChIKey
GJWDRNPPBDVMAH-KPKJPENVSA-N
Physicochemical Property
logP
3.9489
Rotatable Bonds
10
Heavy Atom Count
36
Polar Areas
78.95
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 17866229
ChEMBL ID
CHEMBL53351
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 501.19 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.981 nM
   TI
   LI
   LO
   TS