General Information of the Compound
Compound ID
CP0503564
Compound Name
2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1-[(E)-4-[2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]benzimidazol-1-yl]but-2-enyl]benzimidazole
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Structure
Formula
C44H50N6O2
Molecular Weight
694.924
Canonical SMILES
C(COc1ccc(cc1)-c1nc2ccccc2n1C\C=C\Cn1c(nc2ccccc12)-c1ccc(OCCCN2CCCC2)cc1)CN1CCCC1
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InChI
InChI=1S/C44H50N6O2/c1-3-15-41-39(13-1)45-43(35-17-21-37(22-18-35)51-33-11-29-47-25-5-6-26-47)49(41)31-9-10-32-50-42-16-4-2-14-40(42)46-44(50)36-19-23-38(24-20-36)52-34-12-30-48-27-7-8-28-48/h1-4,9-10,13-24H,5-8,11-12,25-34H2/b10-9+
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InChIKey
APMOACCZLSVUQN-MDZDMXLPSA-N
Physicochemical Property
logP
8.7058
Rotatable Bonds
16
Heavy Atom Count
52
Polar Areas
60.58
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 15291583
ChEMBL ID
CHEMBL314663
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 56 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 9 nM
   TI
   LI
   LO
   TS