General Information of the Compound
Compound ID
CP0502796
Compound Name
(3-{4-[1-(4-{2-[4-(3-Diethylamino-propoxy)-phenyl]-benzoimidazol-1-ylmethyl}-benzyl)-1H-benzoimidazol-2-yl]-phenoxy}-propyl)-diethyl-amine
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Structure
Formula
C48H56N6O2
Molecular Weight
749.016
Canonical SMILES
CCN(CC)CCCOc1ccc(cc1)-c1nc2ccccc2n1Cc1ccc(Cn2c(nc3ccccc23)-c2ccc(OCCCN(CC)CC)cc2)cc1
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InChI
InChI=1S/C48H56N6O2/c1-5-51(6-2)31-13-33-55-41-27-23-39(24-28-41)47-49-43-15-9-11-17-45(43)53(47)35-37-19-21-38(22-20-37)36-54-46-18-12-10-16-44(46)50-48(54)40-25-29-42(30-26-40)56-34-14-32-52(7-3)8-4/h9-12,15-30H,5-8,13-14,31-36H2,1-4H3
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InChIKey
KILHLNJNPKNQHO-UHFFFAOYSA-N
Physicochemical Property
logP
10.038
Rotatable Bonds
20
Heavy Atom Count
56
Polar Areas
60.58
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
56

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 15291586
ChEMBL ID
CHEMBL313692
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3438 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 184 nM
   TI
   LI
   LO
   TS