General Information of the Compound
Compound ID
CP0502241
Compound Name
(4S)-5-Oxo-5-{4-[(pentyloxy)carbonyl]piperazin-1-yl}-4-[({6-phenyl-4-[(tetrahydro-2H-pyran-4-ylamino)carbonyl]pyridin-2-yl}carbonyl)amino]pentanoic Acid
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Structure
Formula
C33H43N5O8
Molecular Weight
637.734
Canonical SMILES
CCCCCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(cc(n1)-c1ccccc1)C(=O)NC1CCOCC1
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InChI
InChI=1S/C33H43N5O8/c1-2-3-7-18-46-33(44)38-16-14-37(15-17-38)32(43)26(10-11-29(39)40)36-31(42)28-22-24(30(41)34-25-12-19-45-20-13-25)21-27(35-28)23-8-5-4-6-9-23/h4-6,8-9,21-22,25-26H,2-3,7,10-20H2,1H3,(H,34,41)(H,36,42)(H,39,40)/t26-/m0/s1
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InChIKey
CGPOZNBLJYDEKC-SANMLTNESA-N
Physicochemical Property
logP
3.0916
Rotatable Bonds
13
Heavy Atom Count
46
Polar Areas
167.47
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45139958
SID: 92389897
ChEMBL ID
CHEMBL590747
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4.6 nM
   TI
   LI
   LO
   TS