General Information of the Compound
Compound ID
CP0500976
Compound Name
2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-benzo[de]isoquinoline-1,3-dione
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Structure
Formula
C27H29N3O3
Molecular Weight
443.547
Canonical SMILES
COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc(C2=O)c34)CC1
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InChI
InChI=1S/C27H29N3O3/c1-33-24-13-3-2-12-23(24)29-18-16-28(17-19-29)14-4-5-15-30-26(31)21-10-6-8-20-9-7-11-22(25(20)21)27(30)32/h2-3,6-13H,4-5,14-19H2,1H3
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InChIKey
GNCURQFERCHEMV-UHFFFAOYSA-N
Physicochemical Property
logP
4.0468
Rotatable Bonds
7
Heavy Atom Count
33
Polar Areas
53.09
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11812299
SID: 16927312
ChEMBL ID
CHEMBL126285
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 40 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 29 nM
   TI
   LI
   LO
   TS