General Information of the Compound
Compound ID
CP0498308
Compound Name
4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-amide
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Structure
Formula
C25H28BrN3O3
Molecular Weight
498.421
Canonical SMILES
COc1ccccc1N1CCN(CCNC(=O)c2cc(Br)c3ccccc3c2OC)CC1
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InChI
InChI=1S/C25H28BrN3O3/c1-31-23-10-6-5-9-22(23)29-15-13-28(14-16-29)12-11-27-25(30)20-17-21(26)18-7-3-4-8-19(18)24(20)32-2/h3-10,17H,11-16H2,1-2H3,(H,27,30)
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InChIKey
SQMUNKWOFRBGIX-UHFFFAOYSA-N
Physicochemical Property
logP
4.1715
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
54.04
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 15232472
ChEMBL ID
CHEMBL30146
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 79.43 nM
   TI
   LI
   LO
   TS