General Information of the Compound
Compound ID
CP0497228
Compound Name
4-((7-(quinolin-2-ylmethoxy)naphthalen-2-ylcarbamoyloxy)methyl)benzoic acid
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Structure
Formula
C29H22N2O5
Molecular Weight
478.504
Canonical SMILES
OC(=O)c1ccc(COC(=O)Nc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1
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InChI
InChI=1S/C29H22N2O5/c32-28(33)22-7-5-19(6-8-22)17-36-29(34)31-24-12-9-20-11-14-26(16-23(20)15-24)35-18-25-13-10-21-3-1-2-4-27(21)30-25/h1-16H,17-18H2,(H,31,34)(H,32,33)
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InChIKey
ZSAJKFANKIXZJV-UHFFFAOYSA-N
Physicochemical Property
logP
6.4139
Rotatable Bonds
7
Heavy Atom Count
36
Polar Areas
97.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44352186
ChEMBL ID
CHEMBL132167
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01800, Cysteinyl leukotriene receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 9 nM
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