General Information of the Compound
Compound ID
CP0496297
Compound Name
(E)-N-[[2-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]phenyl]methyl]-3-phenylprop-2-enamide
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Structure
Formula
C28H31N3O2
Molecular Weight
441.575
Canonical SMILES
COc1ccccc1N1CCN(Cc2ccccc2CNC(=O)\C=C\c2ccccc2)CC1
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InChI
InChI=1S/C28H31N3O2/c1-33-27-14-8-7-13-26(27)31-19-17-30(18-20-31)22-25-12-6-5-11-24(25)21-29-28(32)16-15-23-9-3-2-4-10-23/h2-16H,17-22H2,1H3,(H,29,32)/b16-15+
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InChIKey
OUXSXBHPMQCPQT-FOCLMDBBSA-N
Physicochemical Property
logP
4.347
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
44.81
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11826347
SID: 16943025
ChEMBL ID
CHEMBL127234
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 18 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 325 nM
   TI
   LI
   LO
   TS