General Information of the Compound
Compound ID
CP0495753
Compound Name
6-(3-methoxyphenyl)-9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline
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Structure
Formula
C27H36N2O2
Molecular Weight
420.597
Canonical SMILES
COc1cccc(c1)C1CN2CCCC2c2cc(OCCCN3CCCCC3)ccc12
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InChI
InChI=1S/C27H36N2O2/c1-30-22-9-5-8-21(18-22)26-20-29-16-6-10-27(29)25-19-23(11-12-24(25)26)31-17-7-15-28-13-3-2-4-14-28/h5,8-9,11-12,18-19,26-27H,2-4,6-7,10,13-17,20H2,1H3
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InChIKey
PJOPOUWRRPPODZ-UHFFFAOYSA-N
Physicochemical Property
logP
5.2324
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
24.94
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44438944
ChEMBL ID
CHEMBL238749
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
Ki = 1.7 nM
   TI
   LI
   LO
   TS
2
Ki = 7.5 nM
   TI
   LI
   LO
   TS