General Information of the Compound
Compound ID
CP0493926
Compound Name
1-ethyl-4-fluoro-N-[5-[1-(2-hydroxy-2-methylpropanoyl)-4-methylpiperidin-4-yl]-1,3,4-thiadiazol-2-yl]indazole-6-carboxamide
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Structure
Formula
C22H27FN6O3S
Molecular Weight
474.562
Canonical SMILES
CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(CC1)C(=O)C(C)(C)O
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InChI
InChI=1S/C22H27FN6O3S/c1-5-29-16-11-13(10-15(23)14(16)12-24-29)17(30)25-20-27-26-18(33-20)22(4)6-8-28(9-7-22)19(31)21(2,3)32/h10-12,32H,5-9H2,1-4H3,(H,25,27,30)
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InChIKey
SEEMGOZGWDILNT-UHFFFAOYSA-N
Physicochemical Property
logP
2.9501
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
113.24
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127046441
ChEMBL ID
CHEMBL3799530
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01367, Prostaglandin E2 receptor EP3 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000064 Chem-1 Rattus norvegicus (Rat)  1
1
Ki = 10 nM
   TI
   LI
   LO
   TS