General Information of the Compound
Compound ID
CP0491810
Compound Name
(4aS,10bS)-4-(2-(4-phenylpiperazin-1-yl)ethyl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-9-ol
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Structure
Formula
C25H33N3O
Molecular Weight
391.559
Canonical SMILES
Oc1ccc2CC[C@H]3[C@@H](CCCN3CCN3CCN(CC3)c3ccccc3)c2c1
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InChI
InChI=1S/C25H33N3O/c29-22-10-8-20-9-11-25-23(24(20)19-22)7-4-12-28(25)18-15-26-13-16-27(17-14-26)21-5-2-1-3-6-21/h1-3,5-6,8,10,19,23,25,29H,4,7,9,11-18H2/t23-,25-/m0/s1
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InChIKey
KNPPDPMAXUBRQJ-ZCYQVOJMSA-N
Physicochemical Property
logP
3.7086
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
29.95
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25179491
SID: 57285712
ChEMBL ID
CHEMBL456596
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00957, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 219 nM
   TI
   LI
   LO
   TS
Protein ID: PT01366, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 72.2 nM
   TI
   LI
   LO
   TS