General Information of the Compound
Compound ID
CP0489980
Compound Name
[2-[4-[[(E)-3-(1-methyl-2-oxoquinolin-6-yl)prop-2-enoyl]amino]butyl]-3,4-dihydro-1H-isoquinolin-7-yl] trifluoromethanesulfonate
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Structure
Formula
C27H28F3N3O5S
Molecular Weight
563.598
Canonical SMILES
Cn1c2ccc(\C=C\C(=O)NCCCCN3CCc4ccc(OS(=O)(=O)C(F)(F)F)cc4C3)cc2ccc1=O
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InChI
InChI=1S/C27H28F3N3O5S/c1-32-24-9-4-19(16-21(24)7-11-26(32)35)5-10-25(34)31-13-2-3-14-33-15-12-20-6-8-23(17-22(20)18-33)38-39(36,37)27(28,29)30/h4-11,16-17H,2-3,12-15,18H2,1H3,(H,31,34)/b10-5+
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InChIKey
BNBJYVKSFPTBHW-BJMVGYQFSA-N
Physicochemical Property
logP
3.7348
Rotatable Bonds
9
Heavy Atom Count
39
Polar Areas
97.71
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44297494
ChEMBL ID
CHEMBL292577
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 316.23 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10 nM
   TI
   LI
   LO
   TS