General Information of the Compound
Compound ID
CP0489278
Compound Name
9-(3-(piperidin-1-yl)propoxy)-6-(3-(trifluoromethyl)phenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline
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Structure
Formula
C27H33F3N2O
Molecular Weight
458.568
Canonical SMILES
FC(F)(F)c1cccc(c1)C1CN2CCCC2c2cc(OCCCN3CCCCC3)ccc12
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InChI
InChI=1S/C27H33F3N2O/c28-27(29,30)21-8-4-7-20(17-21)25-19-32-15-5-9-26(32)24-18-22(10-11-23(24)25)33-16-6-14-31-12-2-1-3-13-31/h4,7-8,10-11,17-18,25-26H,1-3,5-6,9,12-16,19H2
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InChIKey
VKNVUSIACZZCCO-UHFFFAOYSA-N
Physicochemical Property
logP
6.2426
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
15.71
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44438926
ChEMBL ID
CHEMBL241473
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
Ki = 2 nM
   TI
   LI
   LO
   TS
2
Ki = 24 nM
   TI
   LI
   LO
   TS