General Information of the Compound
Compound ID
CP0488699
Compound Name
US9206164, 33
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Structure
Formula
C25H28N4O2
Molecular Weight
416.525
Canonical SMILES
Cc1nn(Cc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(C)(C)C)c(C)c1CC(O)=O
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InChI
InChI=1S/C25H28N4O2/c1-15-20(13-23(30)31)16(2)29(28-15)14-17-6-8-18(9-7-17)24-26-21-11-10-19(25(3,4)5)12-22(21)27-24/h6-12H,13-14H2,1-5H3,(H,26,27)(H,30,31)
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InChIKey
KOIBIADLGRZWDP-UHFFFAOYSA-N
Physicochemical Property
logP
5.01614
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
83.8
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122197987
ChEMBL ID
CHEMBL3958283
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01171, Prostaglandin D2 receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000602 ValiScreen human CRTH2 Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.5 nM
   TI
   LI
   LO
   TS