General Information of the Compound
Compound ID
CP0487193
Compound Name
2-[2-(pyridin-3-yloxymethyl)piperazin-1-yl]-6-(trifluoromethyl)-1,3-benzothiazole;hydrochloride
    Show/Hide
Structure
Formula
C18H17F3N4OS
Molecular Weight
394.422
Canonical SMILES
FC(F)(F)c1ccc2nc(sc2c1)N1CCNCC1COc1cccnc1
    Show/Hide
InChI
InChI=1S/C18H17F3N4OS.ClH/c19-18(20,21)12-3-4-15-16(8-12)27-17(24-15)25-7-6-23-9-13(25)11-26-14-2-1-5-22-10-14;/h1-5,8,10,13,23H,6-7,9,11H2;1H
    Show/Hide
InChIKey
YWMKQBCXYCJZEY-UHFFFAOYSA-N
Physicochemical Property
logP
3.5673
Rotatable Bonds
4
Heavy Atom Count
27
Polar Areas
50.28
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 90255122
ChEMBL ID
CHEMBL3262141
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02118, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000868 PC12 Rattus norvegicus (Rat)  1
1
IC50 = 338 nM
   TI
   LI
   LO
   TS