General Information of the Compound
Compound ID
CP0486720
Compound Name
CHEMBL4755563
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Formula
C27H36ClN3O
Molecular Weight
454.058
Canonical SMILES
C[C@H]1CN(CC[C@H]2CC[C@@H](CC2)NC(=O)N(C)c2ccccc2)CCc2ccc(Cl)cc12
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InChI
InChI=1S/C27H36ClN3O/c1-20-19-31(17-15-22-10-11-23(28)18-26(20)22)16-14-21-8-12-24(13-9-21)29-27(32)30(2)25-6-4-3-5-7-25/h3-7,10-11,18,20-21,24H,8-9,12-17,19H2,1-2H3,(H,29,32)/t20-,21-,24-/m0/s1
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InChIKey
KAXUQVAHOIHHMX-HFMPRLQTSA-N
Physicochemical Property
logP
6.0965
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4755563
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 188.7 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 17.2 nM
   TI
   LI
   LO
   TS