General Information of the Compound
Compound ID
CP0486548
Compound Name
1-[1-(2-Cyclopentylamino-ethyl)-1H-indazol-5-yl]-3-(4-phenoxy-phenyl)-urea
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Structure
Formula
C27H29N5O2
Molecular Weight
455.562
Canonical SMILES
O=C(Nc1ccc(Oc2ccccc2)cc1)Nc1ccc2n(CCNC3CCCC3)ncc2c1
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InChI
InChI=1S/C27H29N5O2/c33-27(30-22-10-13-25(14-11-22)34-24-8-2-1-3-9-24)31-23-12-15-26-20(18-23)19-29-32(26)17-16-28-21-6-4-5-7-21/h1-3,8-15,18-19,21,28H,4-7,16-17H2,(H2,30,31,33)
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InChIKey
JGSWRBZQDGUIET-UHFFFAOYSA-N
Physicochemical Property
logP
6.0048
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
80.21
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44402677
ChEMBL ID
CHEMBL196599
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03304, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000016 IMR-32 Homo sapiens (Human)  1
1
IC50 = 2.4 nM
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