General Information of the Compound
Compound ID
CP0485870
Compound Name
(E)-3-(3'-Adamantan-1-yl-4'-hydroxy-biphenyl-4-yl)-N-(2-amino-phenyl)-acrylamide
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Structure
Formula
C31H32N2O2
Molecular Weight
464.609
Canonical SMILES
Nc1ccccc1NC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2
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InChI
InChI=1S/C31H32N2O2/c32-27-3-1-2-4-28(27)33-30(35)12-7-20-5-8-24(9-6-20)25-10-11-29(34)26(16-25)31-17-21-13-22(18-31)15-23(14-21)19-31/h1-12,16,21-23,34H,13-15,17-19,32H2,(H,33,35)/b12-7+
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InChIKey
DWNQOPMOUOSBEO-KPKJPENVSA-N
Physicochemical Property
logP
6.7611
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
75.35
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11784536
ChEMBL ID
CHEMBL188026
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01452, Retinoic acid receptor beta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7 Chlorocebus aethiops (Green monkey)  1
1
EC50 = 17600 nM
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