General Information of the Compound
Compound ID
CP0482630
Compound Name
[1-[(2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-pyridin-3-ylmethanone
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Structure
Formula
C21H24N2O2
Molecular Weight
336.435
Canonical SMILES
O[C@@H]1Cc2ccccc2C[C@H]1N1CCC(CC1)C(=O)c1cccnc1
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InChI
InChI=1S/C21H24N2O2/c24-20-13-17-5-2-1-4-16(17)12-19(20)23-10-7-15(8-11-23)21(25)18-6-3-9-22-14-18/h1-6,9,14-15,19-20,24H,7-8,10-13H2/t19-,20-/m1/s1
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InChIKey
UPRCGEQMNRBTJD-WOJBJXKFSA-N
Physicochemical Property
logP
2.5046
Rotatable Bonds
3
Heavy Atom Count
25
Polar Areas
53.43
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73355119
ChEMBL ID
CHEMBL2409383
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02273, Vesicular acetylcholine transporter
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000868 PC12 Rattus norvegicus (Rat)  1
1
Ki = 24.1 nM
   TI
   LI
   LO
   TS