General Information of the Compound
Compound ID
CP0482447
Compound Name
(4S)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[5-(2-ethoxy-2-oxoethoxy)-1-phenylpyrazole-3-carbonyl]amino]-5-oxopentanoic acid
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Structure
Formula
C26H33N5O9
Molecular Weight
559.576
Canonical SMILES
CCOC(=O)COc1cc(nn1-c1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCN(CC1)C(=O)OCC
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InChI
InChI=1S/C26H33N5O9/c1-3-38-23(34)17-40-21-16-20(28-31(21)18-8-6-5-7-9-18)24(35)27-19(10-11-22(32)33)25(36)29-12-14-30(15-13-29)26(37)39-4-2/h5-9,16,19H,3-4,10-15,17H2,1-2H3,(H,27,35)(H,32,33)/t19-/m0/s1
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InChIKey
AMKNFZWJYVUBKH-IBGZPJMESA-N
Physicochemical Property
logP
1.0781
Rotatable Bonds
12
Heavy Atom Count
40
Polar Areas
169.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44125995
SID: 84977858
ChEMBL ID
CHEMBL2172278
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 372 nM
   TI
   LI
   LO
   TS