General Information of the Compound
Compound ID
CP0481928
Compound Name
(4S)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[(2-phenyl-6-piperidin-1-ylpyrimidine-4-carbonyl)amino]pentanoic acid
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Structure
Formula
C28H36N6O6
Molecular Weight
552.632
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(nc(n1)-c1ccccc1)N1CCCCC1
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InChI
InChI=1S/C28H36N6O6/c1-2-40-28(39)34-17-15-33(16-18-34)27(38)21(11-12-24(35)36)30-26(37)22-19-23(32-13-7-4-8-14-32)31-25(29-22)20-9-5-3-6-10-20/h3,5-6,9-10,19,21H,2,4,7-8,11-18H2,1H3,(H,30,37)(H,35,36)/t21-/m0/s1
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InChIKey
SEULGCSTJMPECM-NRFANRHFSA-N
Physicochemical Property
logP
2.3978
Rotatable Bonds
9
Heavy Atom Count
40
Polar Areas
145.27
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67462328
ChEMBL ID
CHEMBL3322619
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 201 nM
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