General Information of the Compound
Compound ID
CP0477742
Compound Name
(4-cyclobutyl-1,4-diazepan-1-yl)(5-(phenylthio)pyridin-2-yl)methanone
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Structure
Formula
C21H25N3OS
Molecular Weight
367.518
Canonical SMILES
O=C(N1CCCN(CC1)C1CCC1)c1ccc(Sc2ccccc2)cn1
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InChI
InChI=1S/C21H25N3OS/c25-21(24-13-5-12-23(14-15-24)17-6-4-7-17)20-11-10-19(16-22-20)26-18-8-2-1-3-9-18/h1-3,8-11,16-17H,4-7,12-15H2
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InChIKey
QAAWVNPSKXBDHF-UHFFFAOYSA-N
Physicochemical Property
logP
3.9332
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
36.44
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24771015
SID: 49692434
ChEMBL ID
CHEMBL1172076
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 3.7 nM
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