General Information of the Compound
Compound ID
CP0475828
Compound Name
(E)-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-3-naphthalen-2-ylprop-2-enamide
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Structure
Formula
C28H33N3O2
Molecular Weight
443.591
Canonical SMILES
COc1ccccc1N1CCN(CCCCNC(=O)\C=C\c2ccc3ccccc3c2)CC1
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InChI
InChI=1S/C28H33N3O2/c1-33-27-11-5-4-10-26(27)31-20-18-30(19-21-31)17-7-6-16-29-28(32)15-13-23-12-14-24-8-2-3-9-25(24)22-23/h2-5,8-15,22H,6-7,16-21H2,1H3,(H,29,32)/b15-13+
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InChIKey
WZTXLKNXNIFASN-FYWRMAATSA-N
Physicochemical Property
logP
4.5802
Rotatable Bonds
9
Heavy Atom Count
33
Polar Areas
44.81
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11102301
SID: 16174756
ChEMBL ID
CHEMBL126749
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 32 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.68 nM
   TI
   LI
   LO
   TS