General Information of the Compound
Compound ID
CP0475430
Compound Name
N-[1-(1-adamantyl)ethyl]-10-(benzenesulfonyl)-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaen-7-amine
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Structure
Formula
C25H27N5O2S2
Molecular Weight
493.658
Canonical SMILES
CC(Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1ccccc1)C12CC3CC(CC(C3)C1)C2
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InChI
InChI=1S/C25H27N5O2S2/c1-15(25-12-16-9-17(13-25)11-18(10-16)14-25)26-22-21-20(7-8-33-21)30-23(27-22)24(28-29-30)34(31,32)19-5-3-2-4-6-19/h2-8,15-18H,9-14H2,1H3,(H,26,27)
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InChIKey
MNSFFRMNWXMIHG-UHFFFAOYSA-N
Physicochemical Property
logP
5.1886
Rotatable Bonds
5
Heavy Atom Count
34
Polar Areas
89.25
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49799703
ChEMBL ID
CHEMBL1173577
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 221 nM
   TI
   LI
   LO
   TS
2
Ki = 103 nM
   TI
   LI
   LO
   TS