General Information of the Compound
Compound ID
CP0475412
Compound Name
3-(4-hydroxyphenyl)-7-(4-piperidin-1-ylbutoxy)chromen-4-one;hydrobromide
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Structure
Formula
C24H28BrNO4
Molecular Weight
474.395
Canonical SMILES
Br.Oc1ccc(cc1)-c1coc2cc(OCCCCN3CCCCC3)ccc2c1=O
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InChI
InChI=1S/C24H27NO4.BrH/c26-19-8-6-18(7-9-19)22-17-29-23-16-20(10-11-21(23)24(22)27)28-15-5-4-14-25-12-2-1-3-13-25;/h6-11,16-17,26H,1-5,12-15H2;1H
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InChIKey
ZIORHCLOSSQUDK-UHFFFAOYSA-N
Physicochemical Property
logP
5.3884
Rotatable Bonds
7
Heavy Atom Count
30
Polar Areas
62.91
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155556709
ChEMBL ID
CHEMBL4555824
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000043 U2OS Homo sapiens (Human)  1
1
IC50 > 50000 nM
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