General Information of the Compound
Compound ID
CP0474110
Compound Name
N-[5-tert-butyl-3-[3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propylsulfonylamino]-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide
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Structure
Formula
C36H50N4O10S
Molecular Weight
730.881
Canonical SMILES
COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(=O)(=O)CCCNC(CO)(CO)CO)C(C)(C)C
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InChI
InChI=1S/C36H50N4O10S/c1-35(2,3)25-20-29(33(48-4)30(21-25)39-51(46,47)19-7-12-37-36(22-41,23-42)24-43)38-34(45)32(44)28-10-11-31(27-9-6-5-8-26(27)28)50-18-15-40-13-16-49-17-14-40/h5-6,8-11,20-21,37,39,41-43H,7,12-19,22-24H2,1-4H3,(H,38,45)
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InChIKey
FCLNIIIXXITBCL-UHFFFAOYSA-N
Physicochemical Property
logP
2.1154
Rotatable Bonds
18
Heavy Atom Count
51
Polar Areas
195.99
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
12
Complexity
51

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127032198
ChEMBL ID
CHEMBL3785750
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06441, Scavenger receptor class B member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000043 U2OS Homo sapiens (Human)  1
1
IC50 = 50.12 nM
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