General Information of the Compound
Compound ID
CP0471200
Compound Name
N-[4-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]butyl]naphthalene-2-carboxamide
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Structure
Formula
C34H34ClN3O
Molecular Weight
536.119
Canonical SMILES
Clc1ccc2c(CCc3cccnc3C2=C2CCN(CCCCNC(=O)c3ccc4ccccc4c3)CC2)c1
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InChI
InChI=1S/C34H34ClN3O/c35-30-13-14-31-28(23-30)11-10-26-8-5-18-36-33(26)32(31)25-15-20-38(21-16-25)19-4-3-17-37-34(39)29-12-9-24-6-1-2-7-27(24)22-29/h1-2,5-9,12-14,18,22-23H,3-4,10-11,15-17,19-21H2,(H,37,39)
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InChIKey
ZDDZCFWJYDZNBA-UHFFFAOYSA-N
Physicochemical Property
logP
7.0947
Rotatable Bonds
6
Heavy Atom Count
39
Polar Areas
45.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44436756
ChEMBL ID
CHEMBL239493
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 252 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 6.01 nM
   TI
   LI
   LO
   TS