General Information of the Compound
Compound ID
CP0471199
Compound Name
(E)-N-[4-[4-[bis(2-methoxyphenyl)methyl]piperazin-1-yl]butyl]-3-phenylprop-2-enamide
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Structure
Formula
C32H39N3O3
Molecular Weight
513.682
Canonical SMILES
COc1ccccc1C(N1CCN(CCCCNC(=O)\C=C\c2ccccc2)CC1)c1ccccc1OC
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InChI
InChI=1S/C32H39N3O3/c1-37-29-16-8-6-14-27(29)32(28-15-7-9-17-30(28)38-2)35-24-22-34(23-25-35)21-11-10-20-33-31(36)19-18-26-12-4-3-5-13-26/h3-9,12-19,32H,10-11,20-25H2,1-2H3,(H,33,36)/b19-18+
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InChIKey
GJFBEHIWIGLENN-VHEBQXMUSA-N
Physicochemical Property
logP
5.0206
Rotatable Bonds
12
Heavy Atom Count
38
Polar Areas
54.04
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44436741
ChEMBL ID
CHEMBL240564
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 972 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 15.2 nM
   TI
   LI
   LO
   TS