General Information of the Compound
Compound ID
CP0466725
Compound Name
2-[4-[(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-11,15-dimethoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-16-yl]anilino]acetamide
    Show/Hide
Structure
Formula
C32H39N3O4
Molecular Weight
529.681
Canonical SMILES
COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]1(CC[C@@]35C[C@@H]1c1ccc(NCC(N)=O)cc1)OC
    Show/Hide
InChI
InChI=1S/C32H39N3O4/c1-37-24-10-7-21-15-25-30-11-12-32(38-2,23(16-30)20-5-8-22(9-6-20)34-17-26(33)36)29-31(30,27(21)28(24)39-29)13-14-35(25)18-19-3-4-19/h5-10,19,23,25,29,34H,3-4,11-18H2,1-2H3,(H2,33,36)/t23-,25-,29-,30-,31+,32-/m1/s1
    Show/Hide
InChIKey
FDXVKEVTTKXCLD-ZZVPPEEFSA-N
Physicochemical Property
logP
3.9845
Rotatable Bonds
8
Heavy Atom Count
39
Polar Areas
86.05
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 155511793
ChEMBL ID
CHEMBL4436473
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01526, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 57.3 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 16.1 nM
   TI
   LI
   LO
   TS
Protein ID: PT01549, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 40.5 nM
   TI
   LI
   LO
   TS