General Information of the Compound
Compound ID
CP0460995
Compound Name
2-[4-[4-(8-oxo-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene)piperidin-1-yl]butyl]isoindole-1,3-dione
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Structure
Formula
C30H28N2O3S
Molecular Weight
496.632
Canonical SMILES
O=C1N(CCCCN2CCC(CC2)=C2c3ccsc3C(=O)Cc3ccccc23)C(=O)c2ccccc12
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InChI
InChI=1S/C30H28N2O3S/c33-26-19-21-7-1-2-8-22(21)27(25-13-18-36-28(25)26)20-11-16-31(17-12-20)14-5-6-15-32-29(34)23-9-3-4-10-24(23)30(32)35/h1-4,7-10,13,18H,5-6,11-12,14-17,19H2
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InChIKey
REKOUMNGFHDWDG-UHFFFAOYSA-N
Physicochemical Property
logP
5.461
Rotatable Bonds
5
Heavy Atom Count
36
Polar Areas
57.69
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44436751
ChEMBL ID
CHEMBL393775
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1149 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 99.1 nM
   TI
   LI
   LO
   TS