General Information of the Compound
Compound ID
CP0459749
Compound Name
(4S)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-(1-hydroxypropan-2-ylamino)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxopentanoic acid
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Structure
Formula
C26H34N6O7
Molecular Weight
542.593
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(NC(C)CO)nc(n1)-c1ccccc1
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InChI
InChI=1S/C26H34N6O7/c1-3-39-26(38)32-13-11-31(12-14-32)25(37)19(9-10-22(34)35)29-24(36)20-15-21(27-17(2)16-33)30-23(28-20)18-7-5-4-6-8-18/h4-8,15,17,19,33H,3,9-14,16H2,1-2H3,(H,29,36)(H,34,35)(H,27,28,30)/t17?,19-/m0/s1
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InChIKey
IQFLVOVQJYVSHB-NNBQYGFHSA-N
Physicochemical Property
logP
1.2002
Rotatable Bonds
11
Heavy Atom Count
39
Polar Areas
174.29
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67462183
ChEMBL ID
CHEMBL3322637
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 56 nM
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