General Information of the Compound
Compound ID
CP0455296
Compound Name
5-[4-methyl-5-[3-[2-[4-(trifluoromethyl)phenyl]morpholin-4-yl]propylsulfanyl]-1,2,4-triazol-3-yl]pyridine-3-carboxamide
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Structure
Formula
C23H25F3N6O2S
Molecular Weight
506.554
Canonical SMILES
Cn1c(SCCCN2CCOC(C2)c2ccc(cc2)C(F)(F)F)nnc1-c1cncc(c1)C(N)=O
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InChI
InChI=1S/C23H25F3N6O2S/c1-31-21(17-11-16(20(27)33)12-28-13-17)29-30-22(31)35-10-2-7-32-8-9-34-19(14-32)15-3-5-18(6-4-15)23(24,25)26/h3-6,11-13,19H,2,7-10,14H2,1H3,(H2,27,33)
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InChIKey
ODUXFQKZMHFWKP-UHFFFAOYSA-N
Physicochemical Property
logP
3.5505
Rotatable Bonds
8
Heavy Atom Count
35
Polar Areas
99.16
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127040714
ChEMBL ID
CHEMBL3765422
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS