General Information of the Compound
Compound ID
CP0454732
Compound Name
CHEMBL162193
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Formula
C26H28FN3O
Molecular Weight
417.528
Canonical SMILES
Fc1ccc(\C=C\C(=O)N[C@H]2CC[C@H](CCN3Cc4ccc(cc4C3)C#N)CC2)cc1
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InChI
InChI=1S/C26H28FN3O/c27-24-8-2-19(3-9-24)6-12-26(31)29-25-10-4-20(5-11-25)13-14-30-17-22-7-1-21(16-28)15-23(22)18-30/h1-3,6-9,12,15,20,25H,4-5,10-11,13-14,17-18H2,(H,29,31)/b12-6+/t20-,25-
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InChIKey
GISZCUSGSJKNJL-YRDXYIQISA-N
Physicochemical Property
logP
4.79148
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
56.13
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL162193
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 630.96 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 12.59 nM
   TI
   LI
   LO
   TS