General Information of the Compound
Compound ID
CP0452824
Compound Name
(4S)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-(1-oxidopyridin-1-ium-3-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxopentanoic acid
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Structure
Formula
C28H30N6O7
Molecular Weight
562.583
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(nc(n1)-c1ccccc1)-c1ccc[n+]([O-])c1
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InChI
InChI=1S/C28H30N6O7/c1-2-41-28(39)33-15-13-32(14-16-33)27(38)21(10-11-24(35)36)31-26(37)23-17-22(20-9-6-12-34(40)18-20)29-25(30-23)19-7-4-3-5-8-19/h3-9,12,17-18,21H,2,10-11,13-16H2,1H3,(H,31,37)(H,35,36)/t21-/m0/s1
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InChIKey
NQFICBKXLCLFKB-NRFANRHFSA-N
Physicochemical Property
logP
1.7079
Rotatable Bonds
9
Heavy Atom Count
41
Polar Areas
168.97
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67460741
ChEMBL ID
CHEMBL3322630
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 129 nM
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