General Information of the Compound
Compound ID
CP0452822
Compound Name
(4S)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-(2-morpholin-4-ylethylamino)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxopentanoic acid
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Structure
Formula
C29H39N7O7
Molecular Weight
597.673
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(NCCN2CCOCC2)nc(n1)-c1ccccc1
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InChI
InChI=1S/C29H39N7O7/c1-2-43-29(41)36-14-12-35(13-15-36)28(40)22(8-9-25(37)38)32-27(39)23-20-24(30-10-11-34-16-18-42-19-17-34)33-26(31-23)21-6-4-3-5-7-21/h3-7,20,22H,2,8-19H2,1H3,(H,32,39)(H,37,38)(H,30,31,33)/t22-/m0/s1
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InChIKey
CUBJEBATFWEAEL-QFIPXVFZSA-N
Physicochemical Property
logP
1.1516
Rotatable Bonds
12
Heavy Atom Count
43
Polar Areas
166.53
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
10
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67461519
ChEMBL ID
CHEMBL3322618
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 257 nM
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