General Information of the Compound
Compound ID
CP0452809
Compound Name
[2-[4-[[4-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoyl]amino]butyl]-3,4-dihydro-1H-isoquinolin-7-yl] trifluoromethanesulfonate
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Structure
Formula
C30H29F3N4O5S
Molecular Weight
614.646
Canonical SMILES
Cc1nnc(o1)-c1ccc(cc1)-c1ccc(cc1)C(=O)NCCCCN1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1
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InChI
InChI=1S/C30H29F3N4O5S/c1-20-35-36-29(41-20)25-10-6-22(7-11-25)21-4-8-24(9-5-21)28(38)34-15-2-3-16-37-17-14-23-12-13-27(18-26(23)19-37)42-43(39,40)30(31,32)33/h4-13,18H,2-3,14-17,19H2,1H3,(H,34,38)
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InChIKey
OXRRNHYMIXLDFY-UHFFFAOYSA-N
Physicochemical Property
logP
5.50872
Rotatable Bonds
10
Heavy Atom Count
43
Polar Areas
114.63
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44297694
ChEMBL ID
CHEMBL279925
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1.995 nM
   TI
   LI
   LO
   TS