General Information of the Compound
Compound ID
CP0448424
Compound Name
[2-[4-[[(E)-3-quinolin-3-ylprop-2-enoyl]amino]butyl]-3,4-dihydro-1H-isoquinolin-7-yl] trifluoromethanesulfonate
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Structure
Formula
C26H26F3N3O4S
Molecular Weight
533.572
Canonical SMILES
FC(F)(F)S(=O)(=O)Oc1ccc2CCN(CCCCNC(=O)\C=C\c3cnc4ccccc4c3)Cc2c1
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InChI
InChI=1S/C26H26F3N3O4S/c27-26(28,29)37(34,35)36-23-9-8-20-11-14-32(18-22(20)16-23)13-4-3-12-30-25(33)10-7-19-15-21-5-1-2-6-24(21)31-17-19/h1-2,5-10,15-17H,3-4,11-14,18H2,(H,30,33)/b10-7+
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InChIKey
WIWLEFDYNDBBIF-JXMROGBWSA-N
Physicochemical Property
logP
4.4311
Rotatable Bonds
9
Heavy Atom Count
37
Polar Areas
88.6
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 17866221
ChEMBL ID
CHEMBL52901
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 316.23 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.981 nM
   TI
   LI
   LO
   TS