General Information of the Compound
Compound ID
CP0445708
Compound Name
N-benzyl-6-[4-(2-phenylphenyl)piperazin-1-yl]hexanamide
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Synonyms
CHEMBL492871
N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide
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Structure
Formula
C29H35N3O
Molecular Weight
441.619
Canonical SMILES
O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)NCc1ccccc1
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InChI
InChI=1S/C29H35N3O/c33-29(30-24-25-12-4-1-5-13-25)18-8-3-11-19-31-20-22-32(23-21-31)28-17-10-9-16-27(28)26-14-6-2-7-15-26/h1-2,4-7,9-10,12-17H,3,8,11,18-24H2,(H,30,33)
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InChIKey
LQFAQQWXFSOOQJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.3524
Rotatable Bonds
10
Heavy Atom Count
33
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25107518
SID: 56429095
ChEMBL ID
CHEMBL492871
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 161 nM
   TI
   LI
   LO
   TS
Protein ID: PT01746, 5-hydroxytryptamine receptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 0.8 nM
   TI
   LI
   LO
   TS
Protein ID: PT00941, 5-hydroxytryptamine receptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 16.6 nM
   TI
   LI
   LO
   TS
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  1
1
Ki = 503 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide )
Drug Name N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide
Target(s)
Dopamine D2 receptor (D2R)
Inhibitor
5-HT 1A receptor (HTR1A)
Inhibitor