General Information of the Compound
Compound ID
CP0445343
Compound Name
(E)-N-[4-(4-benzhydryl-1,4-diazepan-1-yl)butyl]-3-phenylprop-2-enamide
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Structure
Formula
C31H37N3O
Molecular Weight
467.657
Canonical SMILES
O=C(NCCCCN1CCCN(CC1)C(c1ccccc1)c1ccccc1)\C=C\c1ccccc1
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InChI
InChI=1S/C31H37N3O/c35-30(20-19-27-13-4-1-5-14-27)32-21-10-11-22-33-23-12-24-34(26-25-33)31(28-15-6-2-7-16-28)29-17-8-3-9-18-29/h1-9,13-20,31H,10-12,21-26H2,(H,32,35)/b20-19+
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InChIKey
REVIOUORWMQFEZ-FMQUCBEESA-N
Physicochemical Property
logP
5.3935
Rotatable Bonds
10
Heavy Atom Count
35
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44436731
ChEMBL ID
CHEMBL401223
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 161 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 40.9 nM
   TI
   LI
   LO
   TS