General Information of the Compound
Compound ID
CP0445341
Compound Name
N-[4-(2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaen-5-yl)butyl]thiophene-2-carboxamide
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Structure
Formula
C26H29N3OS
Molecular Weight
431.605
Canonical SMILES
O=C(NCCCCN1CCN2C(C1)c1ccccc1Cc1ccccc21)c1cccs1
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InChI
InChI=1S/C26H29N3OS/c30-26(25-12-7-17-31-25)27-13-5-6-14-28-15-16-29-23-11-4-2-9-21(23)18-20-8-1-3-10-22(20)24(29)19-28/h1-4,7-12,17,24H,5-6,13-16,18-19H2,(H,27,30)
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InChIKey
OXKVUNLFMUWLAP-UHFFFAOYSA-N
Physicochemical Property
logP
4.7258
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44436748
ChEMBL ID
CHEMBL239066
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 497 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 500 nM
   TI
   LI
   LO
   TS