General Information of the Compound
Compound ID
CP0442287
Compound Name
(3-{4-[1-((E)-4-{2-[4-(3-Dimethylamino-propoxy)-phenyl]-benzoimidazol-1-yl}-but-2-enyl)-1H-benzoimidazol-2-yl]-phenoxy}-propyl)-dimethyl-amine
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Structure
Formula
C40H46N6O2
Molecular Weight
642.848
Canonical SMILES
CN(C)CCCOc1ccc(cc1)-c1nc2ccccc2n1C\C=C\Cn1c(nc2ccccc12)-c1ccc(OCCCN(C)C)cc1
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InChI
InChI=1S/C40H46N6O2/c1-43(2)25-11-29-47-33-21-17-31(18-22-33)39-41-35-13-5-7-15-37(35)45(39)27-9-10-28-46-38-16-8-6-14-36(38)42-40(46)32-19-23-34(24-20-32)48-30-12-26-44(3)4/h5-10,13-24H,11-12,25-30H2,1-4H3/b10-9+
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InChIKey
QSZLXCAZDSBUTB-MDZDMXLPSA-N
Physicochemical Property
logP
7.6374
Rotatable Bonds
16
Heavy Atom Count
48
Polar Areas
60.58
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 19938402
ChEMBL ID
CHEMBL87625
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4985 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 144 nM
   TI
   LI
   LO
   TS