General Information of the Compound
Compound ID
CP0442183
Compound Name
(3-{4-[1-((E)-4-{2-[4-(3-Diethylamino-propoxy)-phenyl]-benzoimidazol-1-yl}-but-2-enyl)-1H-benzoimidazol-2-yl]-phenoxy}-propyl)-diethyl-amine
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Structure
Formula
C44H54N6O2
Molecular Weight
698.956
Canonical SMILES
CCN(CC)CCCOc1ccc(cc1)-c1nc2ccccc2n1C\C=C/Cn1c(nc2ccccc12)-c1ccc(OCCCN(CC)CC)cc1
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InChI
InChI=1S/C44H54N6O2/c1-5-47(6-2)29-15-33-51-37-25-21-35(22-26-37)43-45-39-17-9-11-19-41(39)49(43)31-13-14-32-50-42-20-12-10-18-40(42)46-44(50)36-23-27-38(28-24-36)52-34-16-30-48(7-3)8-4/h9-14,17-28H,5-8,15-16,29-34H2,1-4H3/b14-13-
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InChIKey
VZCQCONTEBWWMW-YPKPFQOOSA-N
Physicochemical Property
logP
9.1978
Rotatable Bonds
20
Heavy Atom Count
52
Polar Areas
60.58
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44319269
ChEMBL ID
CHEMBL314937
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1518 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 87 nM
   TI
   LI
   LO
   TS