General Information of the Compound
Compound ID
CP0440542
Compound Name
US9139578, 6
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Structure
Formula
C21H21FN8O6S2
Molecular Weight
564.581
Canonical SMILES
CCOC(=O)CNC(=O)NC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
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InChI
InChI=1S/C21H21FN8O6S2/c1-2-35-17(31)10-25-21(32)28-18(19-30-29-16(36-19)9-26-38(23,33)34)20-27-13-5-3-11(7-14(13)37-20)12-4-6-15(22)24-8-12/h3-8,18,26H,2,9-10H2,1H3,(H2,23,33,34)(H2,25,28,32)
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InChIKey
LHWUYZBNXXSQKI-UHFFFAOYSA-N
Physicochemical Property
logP
1.1252
Rotatable Bonds
10
Heavy Atom Count
38
Polar Areas
204.32
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
11
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 72947551
ChEMBL ID
CHEMBL3920855
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01303, Endothelial lipase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS