General Information of the Compound
Compound ID
CP0439239
Compound Name
(S)-5-oxo-5-(4-(pentyloxycarbonyl)piperazin-1-yl)-4-(2-phenyl-6-(2,2,2-trifluoroethylthio)pyrimidine-4-carboxamido)pentanoic acid
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Structure
Formula
C28H34F3N5O6S
Molecular Weight
625.67
Canonical SMILES
CCCCCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(SCC(F)(F)F)nc(n1)-c1ccccc1
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InChI
InChI=1S/C28H34F3N5O6S/c1-2-3-7-16-42-27(41)36-14-12-35(13-15-36)26(40)20(10-11-23(37)38)33-25(39)21-17-22(43-18-28(29,30)31)34-24(32-21)19-8-5-4-6-9-19/h4-6,8-9,17,20H,2-3,7,10-16,18H2,1H3,(H,33,39)(H,37,38)/t20-/m0/s1
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InChIKey
IKYJUKSLGLNACS-FQEVSTJZSA-N
Physicochemical Property
logP
4.2322
Rotatable Bonds
13
Heavy Atom Count
43
Polar Areas
142.03
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45485881
ChEMBL ID
CHEMBL569911
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 22 nM
   TI
   LI
   LO
   TS