General Information of the Compound
Compound ID
CP0435610
Compound Name
1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-butylurea
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Synonyms
1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-butylurea
1-tert-butyl-3-[2-(4-methylanilino)-5-nitrophenyl]sulfonylurea
284464-83-1
8E9L957C3G
AC1NSM3C
BDBM50188619
BM 573
BM-573
Benzenesulfonamide, N-(((1,1-dimethylethyl)amino)carbonyl)-2-((4-methylphenyl)amino)-5-nitro-
CHEMBL210602
LS-191119
N-tert-butyl-N''-[2-(4-methylphenylamino)-5-nitrobenzenesulfonyl]urea
N-tertbutyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfo nyl]urea
NSC-732094
NSC732094
SCHEMBL3393325
UNII-8E9L957C3G
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Structure
Formula
C18H22N4O5S
Molecular Weight
406.464
Canonical SMILES
Cc1ccc(Nc2ccc(cc2S(=O)(=O)NC(=O)NC(C)(C)C)[N+]([O-])=O)cc1
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InChI
InChI=1S/C18H22N4O5S/c1-12-5-7-13(8-6-12)19-15-10-9-14(22(24)25)11-16(15)28(26,27)21-17(23)20-18(2,3)4/h5-11,19H,1-4H3,(H2,20,21,23)
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InChIKey
SILRUCMXYIKULW-UHFFFAOYSA-N
Physicochemical Property
logP
3.43322
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
130.44
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5312142
SID: 15328505
ChEMBL ID
CHEMBL210602
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01819, Thromboxane A2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 0.78 nM
   TI
   LI
   LO
   TS
2
IC50 = 1.05 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  6
1
IC50 = 53 nM
   TI
   LI
   LO
   TS
2
IC50 = 53.1 nM
   TI
   LI
   LO
   TS
3
IC50 = 318.89 nM
   TI
   LI
   LO
   TS
4
IC50 = 319 nM
   TI
   LI
   LO
   TS
5
IC50 = 620 nM
   TI
   LI
   LO
   TS
6
IC50 = 700 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( BM-573 )
Drug Name BM-573
Target(s)
Thromboxane A2 receptor (TBXA2R)
Inhibitor