General Information of the Compound
Compound ID
CP0432497
Compound Name
4-phenyl-N-[4-[propyl(5,6,7,8-tetrahydroquinazolin-6-yl)amino]butyl]benzamide
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Structure
Formula
C28H34N4O
Molecular Weight
442.607
Canonical SMILES
CCCN(CCCCNC(=O)c1ccc(cc1)-c1ccccc1)C1CCc2ncncc2C1
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InChI
InChI=1S/C28H34N4O/c1-2-17-32(26-14-15-27-25(19-26)20-29-21-31-27)18-7-6-16-30-28(33)24-12-10-23(11-13-24)22-8-4-3-5-9-22/h3-5,8-13,20-21,26H,2,6-7,14-19H2,1H3,(H,30,33)
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InChIKey
UYAJEEPVQYLWDN-UHFFFAOYSA-N
Physicochemical Property
logP
4.9231
Rotatable Bonds
10
Heavy Atom Count
33
Polar Areas
58.12
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44324801
ChEMBL ID
CHEMBL92438
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1258.93 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 125.89 nM
   TI
   LI
   LO
   TS