General Information of the Compound
Compound ID
CP0431702
Compound Name
CHEMBL87753
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Formula
C29H32N4O2
Molecular Weight
468.601
Canonical SMILES
Oc1ccc2ccc(cc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3ccc(cc3CC2)C#N)CC1
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InChI
InChI=1S/C29H32N4O2/c30-19-21-1-4-22-12-15-33(16-13-24(22)17-21)14-11-20-2-8-26(9-3-20)31-29(35)25-6-5-23-7-10-28(34)32-27(23)18-25/h1,4-7,10,17-18,20,26H,2-3,8-9,11-16H2,(H,31,35)(H,32,34)/t20-,26-
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InChIKey
GHSGRKSMXSWZPH-AEEMYVKYSA-N
Physicochemical Property
logP
4.59158
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
89.25
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL87753
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 501.19 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10 nM
   TI
   LI
   LO
   TS