General Information of the Compound
Compound ID
CP0429879
Compound Name
8-butoxy-N-[(4-fluorophenyl)methyl]-7-methoxy-2-oxo-1H-quinoline-3-carboxamide
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Structure
Formula
C22H23FN2O4
Molecular Weight
398.434
Canonical SMILES
CCCCOc1c(OC)ccc2cc(C(=O)NCc3ccc(F)cc3)c(=O)[nH]c12
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InChI
InChI=1S/C22H23FN2O4/c1-3-4-11-29-20-18(28-2)10-7-15-12-17(22(27)25-19(15)20)21(26)24-13-14-5-8-16(23)9-6-14/h5-10,12H,3-4,11,13H2,1-2H3,(H,24,26)(H,25,27)
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InChIKey
JQYZYQKWXGNSIW-UHFFFAOYSA-N
Physicochemical Property
logP
3.7847
Rotatable Bonds
8
Heavy Atom Count
29
Polar Areas
80.42
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53494923
SID: 126722693
ChEMBL ID
CHEMBL1822928
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01298, Cannabinoid receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000102 U-87MG ATCC Homo sapiens (Human)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00834, Cannabinoid receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000102 U-87MG ATCC Homo sapiens (Human)  1
1
Ki = 2.8 nM
   TI
   LI
   LO
   TS