General Information of the Compound
Compound ID
CP0429528
Compound Name
2-(2-cyanoethyl)-3-oxo-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide
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Structure
Formula
C20H16F3N3O3
Molecular Weight
403.36
Canonical SMILES
FC(F)(F)Oc1ccc(CNC(=O)C2N(CCC#N)C(=O)c3ccccc23)cc1
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InChI
InChI=1S/C20H16F3N3O3/c21-20(22,23)29-14-8-6-13(7-9-14)12-25-18(27)17-15-4-1-2-5-16(15)19(28)26(17)11-3-10-24/h1-2,4-9,17H,3,11-12H2,(H,25,27)
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InChIKey
ODMIZDMPOAVBLL-UHFFFAOYSA-N
Physicochemical Property
logP
3.31218
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
82.43
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44543890
SID: 87226702
ChEMBL ID
CHEMBL2164381
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 26000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01105, Sodium channel protein type 5 subunit alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 > 26000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01000, Sodium channel protein type 9 subunit alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 890 nM
   TI
   LI
   LO
   TS
2
IC50 = 11000 nM
   TI
   LI
   LO
   TS